Youth who reside at the facility have access to mental health assessment and treatment. Individualized treatment plans are developed and managed through an interdisciplinary team and services are provided through individual and/or group sessions. There are also a variety of volunteer programs that youth can participate in such as pet therapy. Youth are supported by an inter-disciplinary mental health team made up of a variety of disciplines, including: Child and Youth Workers, Social Workers, Native Service Workers, Nurses, Psychologists, Psychiatrist, Recreation Therapeutic Recreation staff, Art Therapists, and Educators. Residents identify skill deficits that interfere with their life goals as the focus for personal skill development. Dialectical Behaviour Therapy (DBT) is the primary treatment at SAYC. Study of anxiolytic activity of drugs using rats/mice.Kinark and the Syl Apps Youth Centre are committed to delivering evidence-based services.Study of stereotype and anti-catatonic activity of drugs on rats/mice.Anticonvulsant effect of drugs by MES and PTZ method.Effect of drugs on locomotor activity using actophotometer.Effects of skeletal muscle relaxants using rota-rod apparatus.Effect of drugs on ciliary motility of frog oesophagus.Study effect of hepatic microsomal enzyme inducers on phenobarbitone sleeping time in mice.Study of different routes of drugs administration in mice/rats.Maintenance of laboratory animals as per CPCSEA guidelines.Commonly used instruments in experimental pharmacology.Introduction to experimental pharmacology.Note the difference in the onset and severity of catatonic response in both groups. Compare the onset and severity of catatonic response in both groups.Observe and score the severity of catatonic as in step 2. To the second group inject scopolamine and after 30 minutes inject perphenazine into these animals already treated with scopolamine.
Observe the severity of catatonia at 5,15,30,45,60,90 and 120 min after perphenazine.observe the severity of catatonic response (fig 5.14) as follows: Inject perphenazine to control animals.Each group should consist of at least 5 animals. Divide the animals into two groups, one for control (for study of perphenazine effect) and the other for studying the effects of scopolamine. Scopolqmine (dose: 2 mg/kg, ip prepare a stock solution containing 0.4 mg/ml of the drug and inject 0.5 ml/100 g body weight of the animal)Įquipment two wooden blocks, one being 3 cm high and the other 9 cm high Procedure Requirementsĭrugs: Perphenazine (dose: 5 mg/kg ip prepare a stock solution containing 1 mg/ml of the drug and inject 0.5 ml/100g body weight of the animal). Therefore, phenothiazines (choloropromazine or perphenazine) are commonly used to produce parkinson’s-like extrapyramidal symptoms in laboratory animals and to study anti-parkinsonism drugs.The students are advised to know the pharmacology of anti-parkinsonism drugs before performing this experiment. These effects of antipsychotic drugs are due to excessive blockade of dopamine receptors in the extrapyramidal motor system. these effects, such as akinesia, rigidity and tremors, are called parkinson’s- like because in parkinson’s disease the major clinical symptoms include difficulty to move and change posture (akinesia and rigidity) and tremors. Phenothiazine and butyrophenone type of antipsychotic drugs are known to produce extrapyramidal side-effects in man. To study the anticatatonic (antiparkinsonian) effect of scopolamine. To study drug (phenothiazines)- induced catatonia (extrapyramidal side effect in rats Study of stereotype and anti-catatonic activity of drugs on rats/miceīP408P Pharmacology I Practical / S Y B Pharmacy Notes
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